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Compounds that are analog of macrolides that contain lactam rings in place of lactone rings; they are a class of antibiotics. Lactam rings are nitrogen analogs of lactone rings.
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Tacrolimus monohydrate is a macrocyclic lactone that binds to FKBP to form a complex, inhibiting calcineurin phosphatase. This action suppresses T-lymphocyte signal transduction and IL-2 transcription, resulting in immunosuppressive properties. It is intended for research use only.
Inhibits T-lymphocyte signal transduction
Inhibits IL-2 transcription
Immunosuppressive properties
Potentiates glucocorticoid and progesterone actions
May enhance TGFβ-1 gene expression
Inhibits T cell proliferation
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus used as a reference standard for analytical and stability studies. It is intended for research and analytical applications to identify, quantify, and qualify impurity profiles; consult the certificate of analysis for storage and handling details.
Reference impurity of tacrolimus for analytical method development.
Suitable for impurity identification, reporting, and qualification studies.
High-purity material for reliable chromatographic and mass spectrometric analysis (>90.0%).
Supplied as a solid for laboratory use; consult the certificate of analysis for storage instructions.
Molecular formula C44H69NO12 and molecular weight 804.02 for compound identification.
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